hey I’ve never took any peptide my friend is recomending me mk677 and Id like to boost my gym outcomes, but do yall know any peptide for better regeneration? I’ve seen on internet some of them but idk which is the best for sleep and overall regeneration after trainings?

I’m an athlete. I injured my shoulder pretty bad like fully torn the labrum etc. I had my surgery and I’m a few months into recovery and it’s not the same. I want to take bpc 1577 or some other healing peptide. If someone can point me in a direction for better research on dosing and side effects. Thought about taking them as gummies

What's up boys. I just finished Rhonda Patrick's new episode with Charles Brenner (the guy who discovered nicotinamide riboside, AKA NR). Here's everything I learned. My top 10 takeaways: 1. Ok so first off, **buying an "NAD supplement" on Amazon is basically a waste of money**. You're much better off buying a precursor (like NR) and supplementing with that to boost NAD. ([timestamp](https://www.youtube.com/watch?v=ELcVYRJJdK4&t=3426s)) 2. **NR is way more effective than that other NAD precursor (NMN)**. So I'm not an expert but I think NMN is the one David Sinclair preaches about. Charles stressed multiple times that NMN has to be broken down into NR to get into the cell... so you're just better off taking NR. ([timestamp](https://www.youtube.com/watch?v=ELcVYRJJdK4&t=3538s)) 3. **The absolute biggest benefit of taking NR (for healthy people) is exercise recovery**. Apparently used to be common in the Patriots locker room under Belichick. So Brady was definitely taking it. There's photos of Charles Brenner and Belichick out there somewhere. ([timestamp](https://www.youtube.com/watch?v=ELcVYRJJdK4&t=1981s)) 4. Rhonda said she is taking Tru Niagen at the moment (NR) and has been for the last few months ([timestamp](https://www.youtube.com/watch?v=ELcVYRJJdK4&t=4653s)) - they mention in the episode why you want to take it in the morning 5. So this episode was pretty heavy on the biology, but N**AD is this molecule involved in a ton of stuff in the cell (DNA rep

My mom has problems with joint inflammation, every attempt to go to the doctor ended up with lenghthy procedure schedules that at the end did NOTHING. She is in pain every day and goes to do a physical job. From my research, things like BPC-157 and TB-500 could greatly improve her condition. I just don't know how I could possibly convince her that ordering "illegal" chemicals online and injecting yourself is okay. She also has high blood pressure, so would love to know what she shouldn't take.

Cyclist. Not a lifter, but I still do core exercises and some 20-25lb hand weights. I’m 53. Recovering keeps getting harder after intense training. Lots of posts about peptides. I am looking for help with peptide recommendations as a cyclist!! To help make me the best 53 year old cyclist I can be. Any advice would be fantastic!!!

Don't use Anchor Pharma, they are a scam they use Tropical Shipping Lines, also a scam The next douche scammer uses the company name Zhuoyue Biotechnology and they use the shitty scam shipping company called Priority Logistics Express Did I get scammed, yes Did I learn, not with the first one But the excitement of starting, made me disregard all red flags I hope this helps someone Long update!! Ok, so there's an overwhelming theme thats coming through my DMs about sourcing quality and cheap peptides. And unless you already have a vendor who you trust, those 2 things don't work, let alone trust in the source! Take it from me, if you dont have a trusted reliable source, don't chase cheap prices from the factories, you will more than likely get scammed, or playing with your health because you can't really verify what you're injecting! If its your first time, hell, 100th time, use a vendor, pay the % mark up of their product, however, mark-ups vary between 80% +, some as 300 or 400%. Straight from source, slight price variations, but you deal with a product you have no idea about, nor trust it will get to you Using an online established vendor, 80% reliable, safer to deal with, so more trust you get what you pay for, but paying 200% at least mark up for that privilege A grey market recommended vendor, less mark up, less headaches, but less trust than a major vendor You're choice, however, its playing Russian roulette with your health and bank account Take this

I am so long winded so here’s TLDR- I started NAC with NAD+ and coconut MCT oil 600mg once a day for just over 2 months. It seems it could be what has eliminated my alcohol rumination. I see we should be taking breaks. Now that I realize the NAC may be the reason my alcoholic obsessive thoughts have dissipated, I am afraid to stop taking for any time at all. Does anyone have any info on using NAC to quell obsessive thoughts and substance abuse tendencies including any suggested dosing to reduce potential harm? I haven’t noticed negative side affects yet that I can tell. I am not saying this was NAC for sure, but I did start taking it a week or so before I noticed that I hadn’t thought about alcohol in a few days. I will spare the long winded description of how severely addicted I was. Just imagine any and all issues that someone could face from a severe alcohol problem, I hit every milestone a few times. A couple years ago I decided that I would commit to harm reduction drinking and accepted that it might be my reality forever. When I completely cut it out I would fail big. If I drank a few beers most nights, it was rare that I’d spiral with liquor. For at least a year (maybe two), I avoided major binges and my health started to rebound after drenching my organs in vodka every few hours for the good part of a decade. Before, I had to wake up in the night to medicate away the shakes. It was horrible. So going almost 2 years with 2-6 beers a night instead was much better fo

Where did it all start....? I truly believe peptides are as disruptive for human health as AI is for tech. Our way of living (mainly in the west) is disrupting the function of our bodies on a scale that is unprecedented. I believe peptides can, are and will play a huge part in countering this - thus helping millions. A tidal wave is coming. That said in my own endeavours trying to research peptides and after mass-saving browser tabs of PubMed papers and random forums for months, I finally snapped and built a database to organize everything. Shared it in another peptide community 9 days ago and I was blown away by the positive feedback I got. 270 upvotes, 137 comments, genuine positive engagement with constructive feedback in just days... then got banned. Don't know exactly why. Was very clear and open on that I have built it and using the main research part of the platform is free. The reason hasn't been specified so hopefully I get an answer soon in my appeal. Anyways so I figured I'd try here with you degenerate biohackers instead. It's called Peptibase - 97 peptides (and growing) with: \- Mechanisms of action (with PubMed citations) \- Clinical trial dosing insights + Community dosing protocols insights \- Side effects and safety profiles \- Clinical trial status \- Side-by-side comparison tool (I like this one myself a lot) \- Reconstitution calculator (mandatory for a math n00b like myself) \- and more. Below an example of the comparison tool.

“I felt calmer.” “My sleep improved.” “Energy through the roof.” We’ve all written or read reviews like that. But without context, they don’t mean much. If your sleep schedule changed… If you reduced caffeine… If you trained less that week… If life stress dropped… You’re not testing the supplement. You’re testing your week. The hard part about self-experimentation isn’t discipline. It’s removing everything else. If you actually wanted to test something properly, you’d need: • Stable sleep timing • Stable caffeine • Stable training • No travel • No alcohol swings • At least 2–3 weeks per phase And ideally… stop taking it after and see what happens. Almost nobody does that part. Be honest — what’s a supplement you were sure was doing something… until you stopped and realized nothing changed?

Most people have heard of B12, folate, and B6 when it comes to energy, brain function, and methylation. But what about B2? Riboflavin, the scientific name for vitamin B2, is one of those nutrients that rarely gets the spotlight. That is surprising because it sits at the very center of many processes tied to fatigue, mood, and cardiovascular health. # What Vitamin B2 Does Riboflavin is needed to make FAD and FMN, two cofactors that act like spark plugs inside your cells. Without them, your mitochondria cannot run the Krebs cycle efficiently, and energy production slows down. B2 also helps: * Convert folate into its active form (L-5-MTHF), through its role as a cofactor for the MTHFR enzyme. * Activate vitamin B6 by turning it into P-5-P, the form your body actually uses. * Support B12 and folate in lowering homocysteine, an amino acid linked to heart disease risk when levels are too high. * Recycle glutathione, the master antioxidant that protects your cells. # Signs You May Be Low Classic deficiency is rare, but suboptimal status is more common. Warning signs include: * Cracks or sores at the corners of the mouth * Light sensitivity and eye strain * Persistent sore throat * Fatigue that does not respond well to sleep * Homocysteine that stays elevated despite good B6, folate, and B12 intake # Testing Riboflavin Unlike B12 or folate, riboflavin is harder to measure directly. Plasma riboflavin, FMN, or FAD levels can be tested, but they fluctuate depending on what you

There’s so many people out there pushing BPC and telling stories about how great it is, I’m curious about the bad outcomes. Anyone have a personal story they want to share? Or any study that showed negative side effects?

I take quite a few supplements and at age 59, workout religiously, and typically get morning or night time Wood quite often, however, the past two nights it's been out of control, like it won't go down and when it does an hour later I'm waking up again because it's back. Now I view this as a great thing at my age, but nevertheless Im wondering if one of the two things, I just started doing. or taking is contributing to this now out of control wood, even though I've never read or heard that they benefit erections. I started taking BP-157 in pill format, because of shoulder pain, and the past two nights for the first time ever, I used a breathe right nose strip to help me with nose congestion from a cold. I didn't believe in the nose strips, but I'll be damned if I wasn't breathing much easier and congestion free through my nose. Could it be possible that breathing through the nose freely and easier introduces a higher level of Nitric Oxide into the blood stream, thus creating the intense morning wood? Or could the bp-157, be giving me an added boost in that department. I know this is all anecdotal, but wondering if anyone else experienced similar results from one or the other, or even if anyone believes either could actually be contributing in that department.

so my knees have been clicking like crazy lately and I'm finally looking into supplements. Osteo bi-flex seems to be everywhere and i noticed a decent price drop on amazon today ($20-ish for the big pack). I was trying to figure out if the 'triple strength' thing is actually legit or just marketing fluff. i found this review \[[https://jointlabpro.com/reviews/osteo-bi-flex-triple-strength-review-2026/](https://jointlabpro.com/reviews/osteo-bi-flex-triple-strength-review-2026/)\] that says it has some 'joint shield' ingredient that works faster, but I'm always skeptical of those claims. has anyone here actually used it? i don't want to waste money if Move Free or even a generic store brand from walmart does basically the same thing for cheaper. any thoughts/experiences?

I've gotten into supplementation in the past 6 months for health reasons, namely I wanted to maximize my energy, get better quality sleep, and enhance my blood circulation. I did a very wide scope of research but didn't really dig into proper dosages and Tolerable Upper Limits. This week, I've been doing some analysis on my supplements and I realized I've been overdoing it on some supplements, that may have actually been making my fatigue and brain fog worse. The main culprit is a 125mcg (5,000IU) Vitamin D that I've been taking for over two months daily. In my research I came to learn that the tolerable upper limit for Vitamin D is 4,000 IU per day, and regularly exceeding this can result in calcium in your blood that can be terrible for your arteries and soft tissues (like the heart), called Hypercalcemia. Another one that I'm greatly exceeding is Niacin. It's in both my B Complex (25mg) and my Beetroot Concentrate with Nitrates (11mg). TL is 30mg all in, I'm getting 36mg-47mg typically, an excess can cause flushing confusion and even renal failure in very high doses. The National Institute of Health has excellent resources for research, most supplements have a fact-sheet for both medical providers and consumers that breaks down the efficacy in various studies, the tolerable upper limit, and any interactions it might have with medication. I think the most effective supplements I've taken have been Pycnogenol (Pine Bark Extract), L-Citrulline, and L-Ar

I'm taking this zinc supplement because I have some skin problems like dandruff, hair loss, peeling of some parts of my hands and fingers and several rashes that are very itchy and neither fungal creams, shampoos with ketoconazole and oral terbinafine have taken out (now I'm taking terbinafine for nail fungus) Is this supplement good? It's from the company Vidanat (zinc 20 mg) and I have been taking it for almost 3 weeks but recently I started feeling my hands heavier and I can see my veins popping out so I'm now going to take it once every 2 days. Any advice would be welcomed

41 years and i have a focus on longevity. I've considered taking Blueprint Essentials, but that's not complete enough for me, and also quite expensive. Which supplements are not adding any value? \- Vitamine D3 + K2-MK7 \- Omega 3 \- L-Theanine \- Taurine \- Glycine \- CoQ10 \- Nicotinamide Riboside \- Magnesium Malate

**Short of the long** *Lifestyle*: 40 yr male, 200lbs, office job, train jiu jitsu 7-10hrs per week, I eat a 90:10 clean vs lazy indulgences, roughly 2000 calories and IF 16:8 or 18:6, started test and reta right before Christmas and added others later in the cycle *Weekly stack*: 200mg Testosterone Cypionate (~ 14units daily), 5mg Retatrutide (one weekly), 15units 80mg KLOW (5 on/2 off), 500mcg Vitamin B (twice), 15000iu Vitamin D (twice), NAD+ (MWF mornings before 5a BJJ) *Where I need help*: I need help troubleshooting my reta dose. The appetite suppressant seems to be lacking with this titrated up 5mg dose. Like I'm hungry more than normal. I'm also finding it to be a more conscious effort to quiet the food noise. **More details** Started 100mg of test thru my PCP last fall. Brought my numbers up from high 400s to low 700s. It was a once weekly shot on Fridays and honestly didn't notice any benefits. I stopped mid Nov. I asked my Dr about reta and at the time she was unfamiliar and suggested semiglutides or semorelin. Fast forward to the holidays and was introduced to a local source for peptides, mostly interested in BPC 157/TB50p to help with on going recover from BJJ. After talking with this guy and finding out what he had available, I decided to go with Testosterone Cypionate, Reta, KLOW, and NAD+. Started with a base of 200mg test with 3 weekly injections (MWF). I noticed some benefits but also noticed the fluctuation in mood as time passed between doses. At t

Mom had a very early on set of dementia at age 57, trying to figure out best supplement. For my brain, energy and sleep quality. I take mag glycine at night with glynac and 200 mg mag threonate (2 in the morning 2000 mg total). The rest I take in the morning.

I am only familiar with collagen peptide.

After a bout of long covid in the fall of 2022 followed by drastic hormone changes from menopause, I've never regained what used to be my natural state of energy. I couldn’t drink coffee due to my anxiety and caffeine sensitivity and now I drink it every day. I have blood work done regularly for my hormone therapy and am not deficient in anything. I am also on hormone replacement which includes estrogen, progesterone, and testosterone and feel stable. After experimenting with NAD+ initially, after research, I settled on taking MNM and have been taking 500g of Renue’s Pure MNM powder along with 1,250mg of B-12. I’ve been taking creatine for a year and recently increased to 5g, and I take it most days. I take 500mg of ashwagandha at night to help with sleep, stress and anxiety along with magnesium glycinate for sleep and muscle recovery. I just started to take 100mg of rhodiola rosea to help with energy and brain fog and I’ve noticed a difference in cognitive function, which has also been a serious issue from menopause. I take a few other supplements for other things, but they should/do not affect my energy. The only medications I take are 1.25mg of minoxidil and 2.5mg of Finasteride for my hair loss from the testosterone. I have not noticed any difference in fatigue or energy from this. Would love to hear what others are doing.

I am starting an intensive KLOW run for the next 8 weeks pinning 20 units daily (3.3mg GHK-Cu and .66mg others). I currently take 11mg of zinc supplements @12 hours after my pin. Is this sufficient zinc to balance the copper levels? I have seen multiple sites saying take 10-15mg zinc daily and others saying take 10-15mg of zinc per gm of copper. Should I be taking 10mg or 30mg of zinc daily?

I would like to share my story here how the quality of life could be better with higher b12. For a long time my vitamin B12 was “within normal range” on blood tests. I talked about it with my doctor and always got the same answer: everything looks fine, no reason to worry. But I still had symptoms I couldn’t really ignore — brain fog, worse focus, slower thinking, and overall lower cognitive performance. For a long time I blamed stress, sleep or just getting older. The turning point came when I heard one longevity podcasts that lab reference ranges for B12 might be set too low, and that more “functional” levels often start above 500. So i started to track my result with my app juvenis and get guidance from ai. used this protocol for 3 months and still I am using it \-switched supplement to methylcobalamin \-increased B12-rich foods: eggs (min. 4 per day), red meat \~2x/week \-paid attention to timing and absorption — usually took B12 after my second meal \-supported methylation with folate, B6 and magnesium After improving my B12 status, the difference is very real. Much less brain fog, better focus, clearer thinking. Even my day-to-day mood and general vibe feels better. Simply I want to live. What really scares me is how easy it is to ignore symptoms when labs say “normal”. If I didn’t hear about functional B12 ranges, I would probably still still be stuck there. If you’re dealing with brain fog, low energy or cognitive issues and your B12 is on the low end of th

Hi, I’ve been working out like 20 hours a week and am a healthy adult under no medications. I’ve wanted to take some supplements for recovery, improved sleep quality and general longevity. I’ve built this plan with some help of AI. I just wanted to make sure it’s completely safe: Morning Resveratrol (with egg or yogurt) Joint support Lunch L-theanine D3 and K2 Omega 3 Astaxanthin Before bed Ps100 Joint support Glycine Magtein Melatonin Before Training: Creatine Collagen protein

Tonight I was building my first order from iHerb when I noticed a pop-up that said this: >“Special note: Health Canada regulates certain products entering Canada for personal use. Vitamins, supplements, and other health products may be restricted, require a prescription, or be limited in quantity (typically up to a 90-day personal supply). Orders that do not comply with Canadian regulations may be delayed or refused by customs authority. We encourage customers to review Health Canada’s Personal Importation Policy before purchasing.” And then I looked at Health Canada’s Personal Importation Policy, and paused. It’s pretty intense, mentioning that certain food products should not be imported and that there are fines, etc. So I didn’t place my order. I had planned to order some allulose and jiaogulan (Gynostemma pentaphyllum) capsules, which, as far as I know, are not illegal to import, but heck, what do I know? Has anyone had any issues buying allulose or jiaogulan – or anything - from iHerb?

TL;DR: I have been taking 5g/day creatine for 3 years now and am now thinking to increase the per day dosage. After digging into 1000+ studies, I found some wild stuff about high-dose creatine for cognitive function. Single doses of \~20g can increase processing speed by 24.5% and the effects last 9 hours. Also, vegetarians respond \~2x better than meat-eaters. Full breakdown below with sources. Why I did this: I have been taking 5g/day creatine for 3 years now. Like most people, I took the standard "5g per day" advice and never questioned it. It worked fine for my training, but I kept seeing conflicting claims about creatine for brain function. So I started reading actual papers to figure out if I should increase my dosage. 3 months and 1000+ studies later, here are the findings that genuinely surprised me: 1. The "5g for everyone" dose is based on old muscle research, not brain optimization Most dosing recommendations come from 1990s studies measuring muscle saturation. But your brain is different. A 2024 study (Gordji-Nejad et al., Nature Scientific Reports) found that a single high dose of \~0.35g/kg (\~24.5g for a 70kg person) during 21-hour sleep deprivation: • Improved processing speed by 24.5% • Increased brain creatine by 4.2% • Effects peaked at 4 hours and lasted up to 9 hours • Prevented the brain pH drop that normally happens during fatigue Even more interesting: A 2025 review (Fabiano & Candow) analyzed dose-response data and found: • 2-5g/day =

Changing how I take it delivers dramatically different results. Never a chemical on my nails but the simple supplement of bovine collagen powder dissolved in an acid base of apple cider vinegar and most importantly a 1/16 teaspoon of powdered vitamin C. Some believe that coffee provides the acid base, others disagree. Hard as nails in a very short time! Let me know what works for you.

**Morning Supplements:** **Acetyl-l-carnitine - 500 mg** * **Brand:** Jarrow * **Purpose:** Cognition, mental acuity **Berberine - 500 mg** * **Brand:** Pure Encapsulations * **Purpose:** Blood sugar support **Magnesium glycinate- 240 mg** * **Brand:** Jarrow * **Purpose:** cardiovascular & mental health support **Nicotinamide Riboside - 300 mg** * **Brand:** Tru Niagen * **Purpose:** Joint pain reduction, longevity **NMN (nicotinamide mononucleotide) - 250 mg** * **Brand:** Elysium Health * **Purpose:** Joint pain reduction, longevity **N-acetyl-l-cystiene (NAC) - 600 mg** * **Brand:** Jarrow * **Purpose:** Liver support, energy **R-Alpha lipoic acid - 240 mg** * **Brand:** Life Extension * **Purpose:** Metabolic support **Choline & Inositol** \- 250 mg / 250 mg * **Brand:** NOW * **Purpose:** PCOS \-------------------------------------------------------------------------------------- **Afternoon Supplements:** **Multivitamin** * **Brand:** Pure Encapsulations (PureGenomics) * **Purpose:** deficiency prevention **Copper Bisglycinate - 2 mg** * **Brand:** Thorne * **Purpose:** multivitamin lacks copper **DHA + EPA - 650 mg / 200 mg** * **Brand:** Thorne * **Purpose:** brain and cardiovascular health **CoQ10 - 100 mg** * **Brand:** Doctor’s Best * **Purpose:** cardiovascular support **Hyaluronic acid - 240 mg** * **Brand:** Jarrow * **Purpose:** skin & joints **Calcium - 250 mg** * **Brand:** Thorne * **Purpose:** bone support

After a lot of trial and error, these are my top 4 supplements in 2026 1. Astaxanthin – My go-to antioxidant. I like it for overall oxidative stress support, especially with training and daily sun exposure. It just feels like a solid foundational addition. 2. Tocotrienols – A form of vitamin E that I take mainly for skin health and to help support healthy cholesterol levels. I’ve been reading more about their unique benefits compared to standard tocopherols, and they’ve earned a permanent spot in my stack. 3. Bovine Colostrum Powder – I use this primarily for gut health. It seems to help with digestion and overall gut resilience, especially during periods of stress or heavy training. 4. Molecular Hydrogen Tablets – I take these around workouts to support muscle recovery and reduce post-training fatigue. They dissolve in water and are easy to add pre- or post-lift. Curious what everyone else is running in 2026. What are your top 3–5 must-have supplements right now, and why?

Just starting my peptide journey while trying to incorporate supplements. Still learning and dialing things in and would appreciate any advice. Thoughts? Not pictured here is vitamin c 1000mg [](https://www.reddit.com/submit/?source_id=t3_1rey9tq)

Curious if there's anything real to the “beauty from within” category, I decided to conduct an experiment on myself. Tested Glow So Good- here’s my breakdown of the formula, ingredient by ingredient: Astaxanthin- solid literature on photoprotection and oxidative stress in skin. Dose seems to be in line with what the studies are using. Trans-Resveratrol- mostly cardiovascular studies, but some anti-inflammatory studies that might be applicable to acne/aging. Milk Thistle (Silymarin)- while the "liver detox = clear skin" marketing is a bit of a joke, the antioxidant component is real. Oral Hyaluronic Acid- I'm surprised there's as much evidence here as there is. A few RCTs have shown a measurable improvement in hydration at effective doses. Collagen Peptides- this is the most studied ingredient of its kind. Meta-analyses support its use for skin elasticity and hydration. 12 weeks in: skin is definitely smoother, less reactivity around the jawline, and less tightness in the mornings. Confounded by some changes in diet at the same time, so it's hard to say for sure. Main complaint: the amount of the dosage isn’t revealed completely, and I couldn’t find any information about third-party testing. Fillers are none, which appears to be true based on the packaging but hasn’t been confirmed. Does anyone have any experience with Astaxanthin supplements in particular?

guys' testosterone have never been lower and it’s something i can notice all around me. The decline of T in men has been going for years now. There’s microplastics everywhere (including in our balls) and estrogenic shit everywhere that tanks T. Most guys live and eat so different compared to our ancestors which also contributes. The medical system is broken too. The first time I got a blood test to check my levels I had to beg my family female doctor for it. She was asking all these questions and why i wanted to know my T levels. Then they only tested me for total Testosterone, not even Free Testosterone or other important stuff for full optimization.  Today’s accepted “normal” range of T levels are bullshit and have been adjusted to fit the low T epidemic that has been plaguing society.  Before 2017 a testosterone reading under 350 ng/dL was considered “low T” and guaranteed  a testosterone prescription that insurance would cover. Levels that are accepted as normal today would have been laughable just years ago. Here’s a more accurate reference range based on historical testosterone levels of men: **<300 ng/dl - Very Low** **300-500 ng/dl - Low** **500 to 600 ng/dl - Mediocre** **600 to 800 ng/dl - Decent** **800 to 1000 ng/dl - High** **1000+ ng/dl - Gigachad** T is often associated with building muscle but it’s much more than that. T is the elixir of masculinity.  Here are the changes i noticed myself after increasing my T: **-higher sex

I read a ton of stuff on this sub about the potential that we might be massively under-dosing on certain supplements and frankly I find it totally confusing. So I asked Claude to summarize for me all the current research and the frontiers of likely research where confidence is highest that future dosage level recomnendations might be different than they are today. I asked it to use a 40yo male (me) as the target body type. This is the resulting summary and here is the Claude conversation. https://claude.ai/share/15eac917-3595-4a40-aa4a-796645d568e4 Very curious to hear what strikes you as right/wrong on this summary. And don’t worry, I am not changing my dosages based on this. Just curious to see the current state and confidence of dosage guidance.

N=1 Protocol OPTIMIZED v2.4: Pursuing Biological Immortality....(HOMO RHIZOMATICUS) With love, for humanity, forever yours, Optimized\_Rhizo Introduction Can We Live Forever? The ultimate goal of Protocol OPTIMIZED is to radically extend human lifespan potentially approaching biological immortality (negligible aging) by attacking aging on all fronts. Achieving this would mean halting or reversing the cellular and molecular damage that normally accumulates with age. While true immortality remains speculative, this regimen is designed to delay aging indefinitely by targeting known hallmarks of aging, including: • Decline of NAD⁺ • Accumulation of senescent (“zombie”) cells • Telomere shortening • Mitochondrial dysfunction • Chronic inflammation • Loss of proteostasis (protein misfolding/aggregation) • Stem cell exhaustion • Additional upstream/downstream drivers of degeneration Below, the protocol is broken down into daily core practices and periodic interventions, with the mechanism and evidence rationale for each. Potential additions such as rapamycin, fasting strategies, and plasma exchange are also included to improve the odds of achieving unprecedented longevity. Conceptually, this regimen is an Evolutionary Optimization Engine acting on: • Hardware: cells, tissues, organ systems • Software: neural states, cognition, plasticity • Environment: hormetic stressors + recovery architecture Together, these interventions aim to keep metabolism youthful,

What can I add or improve? Current selection For general health: \- omega 3 \- multivit pure encapsulations \- vit d3/k2 \- vit c w bioflavonoids \- magnesium x2 \- pre/probiotic For PCOS \- cinnamon \- biotin \- chromium For leaky gut \- Lglutamine \- tributyrin Deficiencies \- copper About to add / try \- inositol \- NAC \- coq10 What can I add? Priorities: blood sugar regulation, energy increase Thanks in advance

M 28. Working out 6 days a week, playing full court basketball 2/3 times per week, and jiu jitsu 3 times a week. Looking to continue to build my physique and get stronger and more athletic. I sweat like crazy so I’m also supplementing my electrolytes. Am I wasting money with anything here? Anything I need to add? I would prefer to get most of my nutrition through diet.

What makes this stack special is its quality and bioavailability. Nordic Naturals ProOmega 2000 provides a high dose of purified EPA/DHA in triglyceride form for better absorption and heart/brain support. Annatto-E delivers natural tocotrienols, a more potent form of vitamin E than regular tocopherols, with strong antioxidant and cardiovascular benefits. Thorne Basic Nutrients 2/Day uses highly absorbable forms of vitamins and minerals without unnecessary fillers, making it gentle and effective. Together, they cover omega-3s, antioxidant protection, and daily micronutrients Curious to hear what supplements you’re using any favorites, upgrades, or alternatives you’d recommend?

Would love some honest feedback!! Morning \-Thorn Vitamin D3/K2 \- Nordic Naturals Ultimate Omega \-Thorne Basic Nutrients 2/Day (multivitamin) \- Creapure Creatine Monohydrate (3–5g) Evening- \-Doctor’s Best Magnesium Glycinate \-Vital Proteins Collagen Peptides A friend told me about NAD support like elysium. Is it worth it? I want to add a few that would address energy and aging.

Can anyone help me understand how much vitamin D I was given? The picture. A few details (checked 2 months ago): * My vitamin D serum was 20.96 ng/ml * Hemoglobin: 13.1 g/dL * Calcium: 9.5 mg/dL * I’m not sure about my magnesium or vitamin K levels. * Female, mid-20s I received an injection on Saturday, and afterward, I was told to take 50,000 IU weekly. I just got confirmation from my doctor that I can start the supplements, but I don’t know how much was injected in me. I’m unsure if it’s safe to take my first oral dose today. I also have a phobia of vomiting and nausea, which makes this situation more stressful. I don’t want to overdose on vitamin D, but I also want to avoid deficiency. On top of this, I’ve been feeling more anxious lately, with muscle aches, headaches, fatigue, occasional eye discomfort, lightheadedness, and sometimes chest pain. I take a multivitamin and mineral supplement containing 400 IU of vitamin D regularly. I’m just not sure what’s happening with my body right now and how to proceed safely.

Agemate, IM8, novos…. Is there a one stop shop in the longevity supplements? What is the best multi functioning/purpose blend out there?

When I first learned about the importance of glutathione in 2009, there were about 80,000 citations in [PubMed.gov](http://PubMed.gov) about it. From a clinical perspective I knew that glutathione depletion was identified in over 70 health conditions and disease, so I occasionally go back to see who is doing research. Today I did a quick search and was surprised to see that there are now 200,684 citations on glutathione on PubMed, and that the numbers of citations are growing every year with over 10,800 last year. [https://pubmed.ncbi.nlm.nih.gov/?term=glutathione&sort=pubdate](https://pubmed.ncbi.nlm.nih.gov/?term=glutathione&sort=pubdate) Then I switched over to [ClinicalTrials.gov](http://ClinicalTrials.gov) to see what's being researched in the field of glutathione and cysteine; 252 studies in various stages of completion which I found impressive \~ Autism, Diabetes, Parkinson's Disease, hangover, Cystic Fibrosis, HIV, and so much more. I wanted to share these tools here if anyone else is interested to search the supplements you're using and what is being studied. Granted it's not everyone's playground but a fun place if you're curious like me.

Trying to find out more about these 4 substances that would fit into rather the stimulating/dopaminergic/noradrenergic class, iirc? In case you have experience with one or multiple of these i‘d really appreciate any insights, experiences, reviews, information etc. Some questions to the substances each: Does/did it start working from the very first dose on? Do you notice significant profoundly noticeable effects the first time you take it already (instant rapid-acting) hence it also can be used as needed? Or is it like many supplements (fish oil, bacopa, etc.) or antidepressants (ssris etc.) that it must be taken regularly/daily for a long period of time like weeks or months until first effects occur? What would you describe its effects like (e.g. on mood, energy, drive, motivation, anxiety, sociability, talkativeness, cognition, focus/attention, stress etc.)? Is some specific extract or product needed for significant effects? What product and what dose do you take? How often? What situations/purposes is it good for (e.g. studying, socializing, stress, mood, depression, sports, chilling etc.)? What do you use it for? Is it something that could work out for depression, social anxiety & ADD? I suffer from these. After traditional school book medicine didn’t work aka 15+ meds and multiple therapies didn’t do a thing and weren‘t able to reduce my symptoms I have to look out for some alternative ways to touch and reduce my symptoms and treat me. Thanks for any reply!

I want to start by explaining my struggles, and by doing that hopefully creating some sort of relatability in order to reach women who have common struggles, therefore hopefully common solutions! I have had acne since I was about 12 years old, when I first got acne it was primarily on my forehead and chin. At the time, topical solutions worked, specifically Clindamycin and Ketoconazole, (my forehead acne was definitely fungal.) I was stable enough on topical solutions until I turned 16 and got on birth control, at that point my acne completely cleared up! I would only get a cyst on my chin very rarely, maybe once every other month. I was on the combined pill and using topical solutions of Clindamycin, Niacinamide, and Zinc Pyrithione. My skin was very very clear on this combination. I wasn’t on birth control for my acne, so I didn’t even think to blame it either way at the time; whether it was helping or making it worse I didn’t even think about it. I got off after being on the pill for about 2 years? (Possibly only 1.5 years.) I quit because of horrible headaches, and my skin was fine.  For a while, from 18-19 years old my acne was meh, it was worse than it was on birth control, but not so bad that I worried. At some point in the range I decided to stop my usual topical solutions, specifically Clindamycin, (this is where everything begins.) I was using Curology, and I hated being tied to subscriptions for something that I could “fix on my own.” so I bought the same active i

43F Supplementing for general health, longevity, joint support and attempting to improve complexion with regard to both hormonal issues and aging. I know I’ll get some crap for the chewables and gummies, but I can only swallow so many pills before I feel like they are stuck in my throat. At the moment I am taking a low dose of Tirzepatide to lose about 25 lbs (15 lbs to go now!). I will switch to a much lower micro dose once I reach my weight loss goal in a couple of months. At the moment however, the dose I’m currently at reduces my appetite significantly to the point where I don’t think I’m getting enough vitamins/minerals from food so that’s why I bother with the multi vitamin. Plus it’s cheap, tastes good to me, and amounts seem low enough to be non-problematic. I’m also taking the Metamucil daily due to the Tirzepatide. I take metformin for longevity which is why I added the B12 as I read metformin can deplete B12. BioAstin Astaxanthin for my complexion and hopefully some UV protection as I live in a sunny climate. Despite living in a sunny climate I don’t spend much time outdoors Nov-March so I added the D3 K2. One gummy is only 2500 IU D3 which is probably all I need, most other supplements have 5000 IU in one pill so I prefer the dosage of the gummies. I will stop taking the D3 + K2 once I start spending more time outdoors later this spring. I take the spearmint to help control hormonal acne which still plagues me at 43. I find it works. The ceramides I

It's impossible to reach a real human being on Amazon support anymore and they block me from leaving reviews for some reason but I wanted to try to help google results caution people if they search Go look at amazon B00GB85JR4 (not going to link it) see how the labels say "PRODUCT OF USA" and they claim how it's made in USA facility * https://m.media-amazon.com/images/I/81TSSlO0tWL.jpg "PROUDLY MANUFACTURERED IN USA" it's NOT made in the USA it's just BOTTLED in USA and you'd never know because they purposely don't show the back of the real, current, bottle label where it says "IMPORTED INGREDIENTS" almost a QUARTER MILLION positive reviews/ratings Had bought it instead of Doctors Best because that is now owned by China conglomerate and 100% made over there and they have been changing labels and ingredients without notice, and since there's no proof it's real and no punishment for fake supplements, so I wanted to try something USA OH ALSO Their certificate of analysis is FIVE YEARS OLD from 2021 * https://m.media-amazon.com/images/I/81j3UGH3NLL.pdf That might as well be a dish rag for validity on current batch Since you cannot return food or supplements to Amazon (for good reason, I agree with that much) just wanted to try to warn anyone that might question it and search first btw the gelatin capsule shell on NatureWise is way thicker than Doctors Best going to extract the liquid in each brand and compare that too ---------------------------------------

This is a topic I kinda just stumbled on recently but I've been doing a lot of reading on it and figured I'd share what I've found. If this is old news, sorry about that. I personally feel like the importance of our circadian rhythm gets overlookeda a lot when it comes to our overall health. Its also interesting that many of the nutrients I list below are common deficiencies in the USA. I'll throw a few of the papers I've read at the end. I would love to know what others think and if they have any experience with this. Also I'm going to post this in a couple subreddits so apologies if you see it more than once. TL;DR - I'm finding that certain vitamins and minerals have specific roles in supporting circadian rhythm depending on *when* you take them. Our circadian rhythm is driven by clock genes that turn on and off throughout the day. Some nutrients regulate the expression of these genes, while others are required for specific processes carried out by these genes. **Magnesium (evening):** Acts as an NMDA antagonist and GABA agonist for sleep regulation. Boosts the enzyme that makes melatonin. 500mg for 8 weeks increased melatonin and improved sleep in elderly subjects. **Potassium (morning):** Potassium in the morning helps signal daytime to red blood cells, which supports the body's natural circadian rhythm. Potassium levels naturally increase during the day and decrease at night, and research shows that fluctuations in potassium levels impact red blood cells' circad

Lately i’ve been hearing a lot about Beet root supplements to help boost Nitric Oxide levels and other health benefits: antioxidants, cardiovascular support, reduce blood pressure, enhances stamina/recovery, reduces inflammation. With spring around the corner and a desire to increase performance in running/sprint, will it be considered the safest pre workout supplement? I’ve tried before Organic red beet juice crystals, taste is okey and they dissolve well. Any other options?

Hi, my husband and I are always trying new gym sups but particularly preworkout and creatine. Recently, my husband has been liking the Bum supplements preworkout powders and mass gainer. Tonight before the gym he noticed this buried inside the blue raspberry one after taking it for three days already. Can anyone clue me in on what this could possibly be? And have you ever found anything like this inside a can of pre workout or similar? If this is something benign and I’m over reacting I apologize, but It’s definitely not just dry/ clumped powder or separation but a weird, drywall or like Sheetrock (?) pieces that have white fibers inside when broken apart and do not dissolve in water. They also seem to have some kind of paper in them? Emailed raw nutrition/ bum supplements customer email out of health concerns since it’s already been consumed multiple times. Pics below

Hello I used to take curcuminoids for general joint pain/fatigue and they really helped a lot. I stopped taking them while I was pregnant because I just wanted to be extra cautious and I wasn’t sure. I bought them from my chiropractor and they were “Designs for Health” brand. I’d like to start taking them again because I feel they were really great for my overall health helping with inflammation and joint pain. Does anyone have any recommendations on brands/doses? I feel like the designs for health brand was really expensive and while I liked them and will get them again if they are the best out there, I’d like to try to spend a little less if there is a good, effective, reputable brand for less. I don’t want to ask my chiro because he sells them, so he’s of course going to recommend that brand over any others.

I buy all my supplements from various "reputable brands" here in EU. I've been taking 10 000 IU of vitamin D for months (plus calcium and vit K in separate supplements). I was extremely surprised to discover my Vit D metabolite (25OH) was well below norm (21 if I remember, anything below 30 is pretty bad, my doc says she considers 50 to be optimal). My doc prescribed me 8000 IU of prescription Vitamin D daily. After 2 months I was at 35. She then gave me 4000IU for 1 month and 2000IU for 1 month. At that point another test showed 25. So this time I got 10000 IU of prescription Vitamin D again. She says some people need more some less, she is not keen on giving everyone 10k IUs without checking, but it is likely I may actually need that. Now my question. Why did this prescription 8k IU improved my Vit.D metabolites if I was already supposedly taking 10k IUs in supplement form from one of the major brands? My doc just laughed and said "they can put anything in supplements, they are not controlled at all". I used to buy peptides long time ago and back then reputable sellers would include a lab testing report for what they sell. The only type of reports I see supplement sellers propduce are heavy metal ones - to check for cadmium, lead, mercury. Which is fine, at least you know you're not getting poisoned, but how do we know they don't put flour in these capsules? How do you even find a brand that is not scamming? Anyone who suggests reading reviews... serio